Role of plasma adiponectin /C-reactive protein ratio in obesity and type 2 diabetes among African Americans.

reetha Anna Abraham, Selasi Attipoe, Josh B. Kazman, Stacey Anne Zeno, Merrily Poth, Patricia Anne Deuster
Department of Military and Emergency Medicine (MEM) Uniformed Services University of Health Sciences (USUHS)
4301 Jones Bridge Rd, Bethesda, MD 20814 (PA, SA, JK, SZ, PD)
Affiliated Institution(s)
Department of Pediatrics, USUHS (MP)

Abstract
Background: Obesity is a modifiable risk factor for hypertension and T2D.
Objective(s):We examined relations between fasting plasma adiponectin (ADIP), C-reactive protein (CRP) concentrations and markers of T2D in African Americans (AA).

Methods:Fasting plasma ADIP, CRP, Insulin (IN), HOMA-IR, lipid profiles, body fat percent (%BF), waist circumference (WC), body mass index (BMI) and blood pressure measures were determined in AA women (W: n=77) and men (M: n=34). Participants were classified into: 1) Normal fasting glucose (FG) and Normal %BF; 2) Normal FG and High %BF; and 3) High FG.

Results: Compared to men, women had significantly higher mean ADIP (W: 31.4±2.9 vs. M: 18.0±4.4 ng/L), CRP (W: 3.2±0.3 vs. M: 2.0±0.5 mg/L), %BF (W: 41.2±0.9 vs. M: 27.2±1.3), and BMI (W: 32.3±0.7 vs. M: 29.2±1.1 kg/m2). Women with normal FG and %BF had significantly higher ADIP (64.0±6.0) and lower CRP (1.3±0.6) concentrations than normal FG/ high %BF (ADIP: 37.0±5.0 and CRP: 3.1 0.5) and high FG (ADIP: 15.1±4.1 and CRP: 4.0 0.5) groups. Women with high ADIP to CRP ratio had favorable metabolic and anthropometric profiles.

Conclusion:Low ADIP and high CRP are associated with excessive %BF and FG in AA women. ADIP/CRP, may be useful for detecting metabolic dysregulation.

Keywords:Obesity, type 2 diabetes, inflammation.