x
African Health Sciences

    Book Now

    • 256(41)530021
    • info@africanhealthsciences.org
    African Health Sciences
    • info@africanhealthsciences.org
    • Give Feedback
    • Home
    • About Us
    • Staff
    • Focus & Scope
    • For Authors
    • More Links
      • About The Journal
      • Latest Articles
      • Journal Archives
      • Our Events
      • Faq’s
    • Contact Us
    Logo

    Contact Info

    • P. O. Box 7072 Kampala, Uganda
    • +256(41)530021
    • info@africanhealthsciences.org
    • ISSN 1680-6905
    • <!--
    • -->

    10Oct2017

    multi-drug resistant Gram-negative bacteria.

    by admin,  0 Comments

    Anticancer and antibacterial secondary metabolites from the endophytic fungus  Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria.

    Jean-Bosco Jouda, Jean-de-Dieu Tamokou, Céline Djama Mbazoa, Prodipta Sarkar, Prasanta Kumar Bag, Jean Wandji
    1. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaoundé,
    Cameroon
    2. Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
    3. Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata-700 019, India

    Abstract
    Background: The emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need  to search for new effective and safe anti-bacterial agents.

    Objectives: This study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from Penicillium sp.,
    an endophytic fungus associated with leaves of Garcinia nobilis.

    Methods:The culture filtrate from the fermentation of Penicillium sp.was extracted and analyzed by liquid chromatography– mass spectrometry, and the major metabolites were isolated and identified by spectroscopic analyses and by comparison with  published data. The antibacterial activity of the compounds was assessed by broth microdilution method while the anticancer  activity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

    Results:The fractionation of the crude extract afforded penialidin A-C (1-3), citromycetin (4), p-hydroxyphenylglyoxalaldoxime  (5) and brefelfin A (6). All of the compounds tested here showed antibacterial activity (MIC = 0.50 – 128 µg/mL) against Gramnegative multi-drug resistance bacteria, Vibrio cholerae (causative agent of dreadful disease cholera) and Shigella flexneri (causative  agent of shigellosis), as well as the significant anticancer activity (LC 50 = 0.88 – 9.21 µg/mL) against HeLa cells.

    Conclusion:The results obtained indicate that compounds 1-6 showed good antibacterial and anticancer activities with no  toxicity to human red blood cells and normal Vero cells.

    Keywords: Garcinia nobilis, endophytic fungi, secondary metabolites, antibacterial activity, anticancer activity.

    Related posts:

    Prevalence and factors associated with anthropometric failure

    Comparing concentration methods

    Stroke in patients with diabetes mellitus

    Recent Posts

    • Editor’s choice: Tackling infectious diseases, NCDs and sexual reproductivehealth issues as we enter our 24th year of remarkable growth
    • Preconception and contraceptive care for women living with HIV/AIDSattending antiretroviral treatment clinics in Lagos State, Nigeria
    • Effects of SNPs on TNF-α and IL-10 cytokine expression in TB and HIVpatients in the Capricorn district, Limpopo Province, South Africa
    • Prevalence of Schistosomiasis in a neglected community, South western Nigeria at two points in time, spaced three years apart
    • Review of Leishmaniasis in the Middle East and North Africa

    Recent Comments

    No comments to show.

    Archives

    • April 2024
    • May 2019
    • April 2019
    • September 2018
    • August 2018
    • January 2018
    • December 2017
    • November 2017
    • October 2017
    • September 2017

    Categories

    • 2001 Issues
    • 2002 Issues
    • 2003 Issues
    • 2004 Issues
    • 2005 Issues
    • 2006 Issues
    • 2007 Issues
    • 2008 Issues
    • 2009 Issues
    • 2010 Issues
    • 2011 Issues
    • 2012 Issues
    • 2013 Issues
    • 2014 Issues
    • 2015 Issues
    • 2016 Issues
    • 2017 Issues
    • 2018 Issues
    • 2019 Issues
    • 2024 Issues
    • Articles
    • December issue
    • December Release
    • June Issue
    • June Release
    • March Issue
    • March Issue
    • March Release
    • News
    • number / volume 2
    • number /volume 1
    • number /volume 1
    • number /volume 1 2008
    • number 1
    • number 1
    • number 1
    • number 1
    • number 1
    • number 1
    • number 1
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2 special Issue
    • number 2 special Issue 2
    • number 3
    • number 3
    • number 3
    • number 3
    • number 3
    • number 3
    • number 3
    • number 4
    • number 4
    • number 4
    • number 4
    • number 4
    • number 4
    • number/ volume 3 2008
    • number/ volume 4 2008
    • number/volume 1
    • number/volume 1
    • number/volume 2
    • number/volume 2
    • number/volume 2 2008
    • number/volume 3
    • number/volume 3
    • number/volume 3
    • number/volume 4
    • number/volume1
    • September Issue
    • September Release
    • Special Edition
    • special Issue
    • Uncategorized
    • Vol. 24 No. 1 (2024)
    • volume 1
    • volume 1
    • volume 1
    • volume 2
    • volume 2
    • volume 2
    • volume 2
    • volume 2
    • volume 3
    • volume 3
    • volume 3
    • volume 3
    • volume 4
    • volume 4
    • volume 4
    • volume 4
    • volume1

    Categories

    • 2001 Issues
    • 2002 Issues
    • 2003 Issues
    • 2004 Issues
    • 2005 Issues
    • 2006 Issues
    • 2007 Issues
    • 2008 Issues
    • 2009 Issues
    • 2010 Issues
    • 2011 Issues
    • 2012 Issues
    • 2013 Issues
    • 2014 Issues
    • 2015 Issues
    • 2016 Issues
    • 2017 Issues
    • 2018 Issues
    • 2019 Issues
    • 2024 Issues
    • Articles
    • December issue
    • December Release
    • June Issue
    • June Release
    • March Issue
    • March Issue
    • March Release
    • News
    • number / volume 2
    • number /volume 1
    • number /volume 1
    • number /volume 1 2008
    • number 1
    • number 1
    • number 1
    • number 1
    • number 1
    • number 1
    • number 1
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2
    • number 2 special Issue
    • number 2 special Issue 2
    • number 3
    • number 3
    • number 3
    • number 3
    • number 3
    • number 3
    • number 3
    • number 4
    • number 4
    • number 4
    • number 4
    • number 4
    • number 4
    • number/ volume 3 2008
    • number/ volume 4 2008
    • number/volume 1
    • number/volume 1
    • number/volume 2
    • number/volume 2
    • number/volume 2 2008
    • number/volume 3
    • number/volume 3
    • number/volume 3
    • number/volume 4
    • number/volume1
    • September Issue
    • September Release
    • Special Edition
    • special Issue
    • Uncategorized
    • Vol. 24 No. 1 (2024)
    • volume 1
    • volume 1
    • volume 1
    • volume 2
    • volume 2
    • volume 2
    • volume 2
    • volume 2
    • volume 3
    • volume 3
    • volume 3
    • volume 3
    • volume 4
    • volume 4
    • volume 4
    • volume 4
    • volume1

    Archives

    • April 2024
    • May 2019
    • April 2019
    • September 2018
    • August 2018
    • January 2018
    • December 2017
    • November 2017
    • October 2017
    • September 2017

    Tags

    Achives Latest News


    ISSN 1680-6905

    • P. O. Box 7072 ,Kampala, Uganda
    • Call Us: 256(41)530021
    • info@africanhealthsciences.org

    Latest Activities

    Usefull Link

    • About AHS
    • Services
    • Focus & Scope
    • Our Articles
    • Contact Us

    Subscribe

    For research updates from African Health Sciences, sign up now!

      African Health Sciences © All Right Reserved