Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.

Jia-Jun Ye, Tian-Biao Zhou, Yun-Fang Zhang, Qi Wang, Yan-Yan Su,Jia-Min Tang, Hong-Yan Li
1. Department of Nephrology, Huadu District People’s Hospital, Southern Medical University,
Guangzhou 510800, China
2. Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou
510655, China

Abstract:
Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24,  subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.

Method: In this study, 24 ESRD patients and 24 healthy controls were included.

Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P﹤0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from  healthy controls (50.18±21 vs 7.78±1.31; P﹤0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P﹤0.01).

Conclusion:VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

Keywords:Vitamin D receptor (VDR), CYP24A1, end-stage renal disease (ESRD