Impact of weight loss on oxidative stress and inflammatory cytokines in obese type 2 diabetic patients.
Shehab M. Abd El-Kader, Mohammed H Saiem Al-Dahr.

1. Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
2. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.

Abstract
Background:Type 2 diabetes mellitus is associated with abnormal markers of inflammatory cytokines and oxidative stress  markers. Although, these abnormalities could be modulated with weight reduction; there is limitation in clinical studies that have  addressed the beneficial effects of weight reduction in modulating biomarkers of inflammatory cytokines and oxidative stress  for obesity associated with type 2 diabetes mellitus.

Objective: This study was designed to detect the effects of weight loss on the inflammatory cytokines, oxidative stress markers
in obese type 2 diabetic patients.  Material and Methods:Eighty obese patients with type 2 diabetes mellitus, their age ranged from 35-57 years and their body  mass index ranged from 31-35 kg/m2 were equally assigned into 2 groups: the weight reduction group received aerobic exercises,  diet regimen, where as the control group received medical treatment only for 12 weeks.

Results:The mean values of body mass index (BMI), tumor necrosis factor–alpha (TNF-α), interleukin-6 (IL-6), C-reactive  protein (sCRP), conjugated dienes (CD) and malondialdehyde (MDA) were significantly decreased, while the mean values of  glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were significantly increased in patients of  group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the  investigated parameters in group (A) and group (B) at the end of the study.

Conclusion: Weight loss ameliorates inflammatory cytokines and oxidative stress markers in obese type 2 diabetic patients.

Keywords: Type 2 diabetes, weight reduction, oxidative stress, cytokines, obesity.