Oluwatosin Oladosu-olayiwola¹, Hannah Olawumi², Abiola Babatunde², Munirdeen Ijaiya³,Idayat Durotoye², Sikiru Biliaminu⁴, Rasheedat Ibraheem⁵

1. Lautech Teaching Hospital, Haematology and blood transfusion.
2. University of Ilorin, Haematology and blood transfusion.
3. University of Ilorin / University of Ilorin teaching hospital., Obstetrics & Gynaecology.
4. University of Ilorin Teaching Hospital, Chemical Pathology and Immunology.
5. University of Ilorin Teaching Hospital, Paediatrics and Child Health.

Abstract

Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because  of  endothelial  activation with  resultant  production  of  some  endothelial  derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women.

Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant  women  as  controls.  Levels  of  PT,  aPTT,  tPA,  PAI-1, D-dimer  protein    were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on  their  urine  samples.  Data  generated  was  analysed  using  the IBM®SPSS  20.0 (2011) soft ware packages and the level of significance was a p-value <0.05.

Results:  The mean age of the respondents  was 29.9±5.2 years. The  median(25^th-75^th percentile)  values  of  D-dimer,   tPA, and PAI-1  of  subjects  were  730  (305.000-1560.000ng/ml),   0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively which were significantly higher than the corresponding   values  in  the  controls  of  520  (24.000-1030.000ng/ml),   0.05 (0.040-0.090ng/ml  and  2.650 (2.125-3.400ng/ml) respectively, p<0.05 each.

Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition. Keywords:  Fibrinolysis, pregnancy ,pre-eclampsia.

DOI: https://dx.doi.org/10.4314/ahs.v18i3.15

Cite as: Oladosu-olayiwola O, Olawumi H, Babatunde A, Ijaiya M, Durotoye I, Biliaminu S, Ibraheem R. Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria. Afri Health Sci. 2018;18(3): 576-583. https://dx.doi.org/10.4314/ahs.v18i3.15