Nawal Helmi¹,  Hani Choudhry^1,2, Qari M³, Taha A Kumosani^1,2,4,5, Abdulrahman L AL-Malki^1,2,6, Said Salama Moselhy^1,4,6,7, Afnan T Kumosani⁸

1. Biochemistry Department, Faculty of science, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi
2. Cancer Metabolism and Epigenetic Unit, Faculty of Science (KAU) ; Cancer and Mutagenesis Unit, King Fahd Medical Research Center (KAU).
3. Hematology department, Faculty of medical science, King Abdulaziz University, Saudi Arabia.
4. Experimental biochemistry unit, King Fahd Medical Research center , KAU.
5. Production of bio products for industrial applications   research Group, KAU.
6. Bioactive Natural Products Research Group, KAU.
7. Biochemistry department, Faculty of science, Ain Shams University, Cairo, Egypt.
8. Department of pathology and Laboratory Medicine, Blood Bank Transfusion medicine, King Abdulaziz Medical City, Jeddah, National Guards, , Jeddah, 21423.

Abstract

Background: The current study evaluated level of serum asymmetric dimethylarginine (ADMA) and its association to cardiac biomarkers in thalassemia patients for early diagnosis of abnormality in myocardial infarction.

Subjects and methods: This study was conducted on 80 subjects divided into four groups each with 20 subjects. Group I: Control: healthy subjects. Group II: Myocardial infarction: Patients with elevated serum troponin T. Group III: thalassemia patients. Group IV: thalassemia with myocardial   infarction patients:  Included 20 thalassemia patients   with Myocardial   infarction. Serum samples were subjected for assay of creatine kinase (CK:MB), Lactate dehydrogenase, troponin I ,ADMA,  Serum MDA level was  determined.

Results: Data obtained showed that serum   CKMB, LDH1, AST, Troponin T and ADMA levels were significant elevated in MI with or without  Thalassemia  compared with control groups. Serum MDA was statistically significantly elevated in MI with or without Thalassemia compared with control groups. The serum level of troponin T showed an area under curve (AUC) of 0.92 ,(sensitivity 91.0 % and specificity, 88%). Also, the ADMA supported the diagnostic profile, showing an AUC of 0.85 with (sensitivity, 92.0%; specificity, 91,9%).

Conclusion: Serum ADMA is sensitive marker for incidence of MI in thalassemia patients.

Keywords: CKMB, LDH1, AST, Troponin T, asymmetric dimethylarginie, Thalassemia.

DOI: https://dx.doi.org/10.4314/ahs.v18i3.30

Cite as: Helmi N, Choudhry H, Qari M, Kumosani TA, AL-Malki AL, Moselhy SS, Kumosani AT. Association of serum asymmetric dimethyl-arginine and troponin I levels as a risk of myocardial infarction in thalassemia. Afri Health Sci. 2018;18(3): 720-726.  https://dx.doi. org/10.4314/ahs.v18i3.30