Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Kawasaki disease: a meta-analysis.

Yan Pan1, Hongzhu Lu1,2
1. Department of Pediatrics, the First Affliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
2. Medical College of Yangtze University, Jingzhou, Hubei Province, China.

Abstract
Background: The angiotensin-converting enzyme (ACE) I/D polymorphism has been reported to be associated with Kawasaki disease(KD) ,but studies to date present conflicting results.

Objectives: The aim of this study is to derive a more precise estimation of the association between the ACE I/D polymorphism
and KD risk.

Methods: PubMed,EMBASE,CNKI and Wangfang databases were retrievaled to identify for relevant studies from inception to
May 2017.Pooled odds ratios (OR) with 95% confdence intervals (CI) were calculated using Stata 12.0 software.

Results: A total of 6 case-control studies comprising 634 patients and 458 controls were included in the meta-analysis,and we
found a signifcant association between the ACE I/D polymorphism and KD risk(D vs I:OR = 0.81, 95%CI = 0.31-2.11;DD vs II: OR = 1.03, 95%CI = 0.42-2.54; DI vs II: OR = 1.44, 95%CI = 1.09-1.90; dominant model: OR = 1.43, 95%CI = 1.11-1.85; recessive model: OR = 1.21, 95%CI = 0.44-3.29 ).When stratifed by sample size>200, this polymorphism is associated with an increased the risk of KD.

Conclusion: The I/D polymorphism in the ACE gene may be associated with susceptibility to KD.

Key words: ACE,I/D polymorphism, Kawasaki disease