Olusola Adedeji Adejumo1, Bolanle Olusola-Faleye2, Victor Adepoju2, Abimbola Bowale1, Sunday Adesola1, Ayodeji Falana1, Henry Owuna1, Kehinde Otemuyiwa1, Shafaatu Oladega1, Oluwatosin Adegboye2
1. Mainland Hospital, Yaba Lagos Nigeria.
2. KNCV TB Foundation Nigeria/Challenge TB project, Lagos Nigeria.
Abstract
Background: Nigeria is one of the 30 high burden countries for drug resistant tuberculosis (DR-TB). This study assessed the prevalence and factors associated with rifampicin resistant tuberculosis (RR-TB) in a secondary referral hospital in Lagos State Nigeria.
Methods: A retrospective review of presumptive TB register of patients screened for Mycobacterium tuberculosis (MTB) and RRTB using Xpert MTB/RIF assay at Mainland hospital between January 1 2012 and December 31 2016 was conducted.
Results: A total of 2497 clients were screened for MTB and RR-TB during the study period. The majority (51.4%) were between 25 – 44 years. Male: Female ratio was 1:0.8. Of the 2497 clients screened, MTB was detected in 942 (37.7%) out of which 220 (23.4%) had RR-TB. Age (AOR 1.8, 95%CI 1.3- 2.6, p = 0.001), symptomatic contact with DR-TB patients (AOR 3.3, 95%CI 2.1-5.1, p <0.001) and type of TB (AOR 2.9, 95% CI 1.7 – 5.0, <0.001) were associated with RR-TB after adjusting for age, gender, HIV status and symptomatic contacts with DR-TB patients.
Conclusion: The prevalence of RR-TB in new and previously treated TB patients was high in this study. Urgent steps are needed to avert an impending RR-TB epidemic
Keywords: Rifampicin resistance, tuberculosis, Xpert MTB/RIF, Lagos.
DOI: https://dx.doi.org/10.4314/ahs.v18i3.2
Cite as: Adejumo OA, Olusola-Faleye B, Adepoju V, Bowale A, Adesola S, Falana A, Owuna H, Otemuyiwa K, Oladega S, Adegboye O.
Prevalence of rifampicin resistant tuberculosis and associated factors among presumptive tuberculosis patients in a secondary referral hospital in Lagos Nigeria. Afri Health Sci. 2018;18(3): 472-478. https://dx.doi.org/10.4314/ahs.v18i3.2