Alkireidmi MA^1,3, Al-Abbasi  FA¹ , Mehanna MG¹, Said S Moselhy^1,2

1. Department of Biochemistry, Faculty of science, King Abdulaziz University, Jeddah, Saudi Arabia.
2. Department of Biochemistry, Faculty of science, Ain Shams University, Cairo, Egypt.
3. King Saud bin Abdul Aziz university for health sciences, college of science and health professions, Basic science department. Jeddah, Saudi Arabia.

Abstract

Objective: The use of a biomarker was extremely useful in clinical emergencies such as stroke to aid in triage and early management of cases. The diagnostic accuracy of laboratory biomarkers is run to approve the identification of easy, cheap and fast tests associated with cerebral ischemia and intracranial hemorrhage. The present study was designed to screen serum enolase activity, activities of CK-BB, LDH and   lipid profile   in patients with ischemic or related diseases as good diagnostic/ prognostic indicator for ischemic diseases.

Methods: Sixty male subjects in the age range of (45 ±2years)  were divided into four groups each  with 15 participants: Group (I) normal . Group (II) patients recently diagnosed as ischemic disease; Group (III) hypertensive patients and Group (IV); diabetic patients enolase activity (p<0.001) and CK-BB (p<0.01) in ischemic and hypertensive patients compared with control and diabetic groups. LDH level  was significantly elevated in ischemic, hypertensive and diabetic patients compared with controls (p<0.001). The cut -off value for serum enolase was 62.5 nmol/l showing 90% sensitivity and 93% specificity for differentiation of ischemic disease. Positive correlations were observed between serum enolase (r = 0.56), and CK-BB (r = 0.53).

Conclusion: Serum enolase can be considered as a more sensitive and specific marker and used as a sensitive diagnostic or prognostic marker for ischemic related diseases.

Keywords: Serum enolase, ischemia, hypertension, diagnosis, prognostic.

DOI: https://dx.doi.org/10.4314/ahs.v18i2.13

Cite as: Alkireidmi MA, Al-Abbasi  FA, Mehanna MG, Moselhy SS. Biochemical markers as diagnostic/prognostic  indicators  for ischemic disease. Afri Health Sci. 2018;18(2):  287-294. https://dx.doi.org/10.4314/ahs.v18i2.13

 Biochemical markers as diagnostic prognostic indicator for ischemic disease .PDF