Changes in platelet functional parameters and CD62 P expression in liver cirrhosis

G Xianghong, C Guanping, Y Fenghua, W Jiayin

Abstract

Background: Hepatic impairment, portal hypertension, and multi-systemic damage could occur during liver cirrhosis’s late stage. Bleeding is a complication of hepatic cirrhosis along with several changes including blood platelet count (BPC), mean platelet volume (MPV), platelet crit (PCT) and expression of platelet CD62P. Blood platelet count (BPC), mean platelet volume (MPV), platelet distribution width, and other indices are indirect reflections of CD62P parameters.

Objective: To investigate the changes in platelet functional parameters and CD62 P expression in liver cirrhosis as a possible guide in clinical treatments and prognoses of liver cirrhosis.

Methods: CD62P was tested by flow cytometry in liver cirrhosis. BPC, MPV, and PCT in peripheral blood were tested using an auto blood cell analyzer. Data were analyzed using SPSS11.0.

Results: The values of CD62P and MPV in patients was significantly higher than those of healthy donors (PConclusions: CD62P, BPC, MPV, and platelet crit (PCT) show several changes in liver cirrhosis. It is useful to understand the relationship between hepatic cirrhosis severity and CD62P, BPC, MPV, PCT, timely monitoring of CD62P for treatment of hepatic cirrhosis in clinical treatment and prognosis.

Keywords: Liver cirrhosis, granula protein, platelet parameters, expression