Synthesis, characterization and biological activities of substituted cinnoline culphonamides

S Vikas, S Darbhamulla

Abstract

Background: The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties.

Methods: In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity.

Results: These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity.

Conclusion: Further investigations are required to find out possible mechanism of action.

Keywords: Cinnoline, Antibacterial, Antifungal