Relationship between IL-10 gene -819C/T polymorphism and the risk of  inflammatory bowel disease: a meta-analysis.

Haien Wu1,2, JingJing Guo,Yajun He, Hekun Yin, Jianchang Shu
1. Department of Gastroenterology, Guangzhou Red Cross Hospital, Medical College, Jinan University,
Guangzhou 510220,China;
2. Department of Gastroenterology, Jiangmen Central Hospital, Jiangmen 529030,China;
3. Department of Nephrology, Jiangmen Central Hospital, Jiangmen 529030,China;
4. Center of Clinical Laboratory Medicine, Guangzhou Red Cross Hospital, Medical College, Jinan University,
Guangzhou 510220,China.

Abstract
Background: The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory  bowel disease (IBD) ,but the previous results are conflicting.

Materials and methods: The present study aimed at investigating the association between this polymorphism and risk of IBD  using a meta-analysis.PubMed,Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI)  databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio  (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models.

Results:A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and  our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64-1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI  0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and  Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn’s disease(CD)(CT vs.  CC:OR=0.68,95%CI 0.48-0.97).

Conclusion: In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated  with CD risk.

Keywords: Interleukin 10, -819C/T polymorphism, inflammatory bowel disease