Association of interleukin 17 / angiotensin II with refractory hypertension risk in  hemodialysis patients.

Zebin Wang, Wei Shi, Xinling Liang, Wenjian Wang, Jianbo Liang
1. Southern Medical University, Guangzhou, China
2. Department of Nephrology, Guangdong General Hospital,
Guangdong Academy of Medical Hospital, Guangzhou, China
3. Department of Nephrology, The Second Affiliated Hospital of GuangZhou
Medical University, Guangzhou, China.

Abstract
Objective: The study was performed to investigate the association of interleukin 17 (IL 17) or angiotensin II (Ang II) with  refractory hypertension risk in hemodialysis patients.

Methods:Ninety hemodialysis patients were enrolled into this study, and those with hypertension were divided into two groups.  The Easy-to-Control Hypertension group (ECHG) had fifty patients, while the refractory hypertension group (RHG) had forty  patients. Twenty healthy individuals were recruited as the control group. IL17 and Ang II were determined using a human IL 17  / Ang II enzyme-linked immunosorbent assay kit. Serum IL 17 and Ang II concentrations in RHG patients were higher than  those in ECHG patients.

Results:Serum IL 17 and Ang II concentrations in both patient groups were higher than those in the control group. Linear  regression analysis showed a positive correlation between IL 17 and Ang II. In multivariate regression analysis, we found that  IL17 and Ang II were associated with refractory hypertension risk in hemodialysis patients.

Conclusion: IL17 and Ang II were associated with refractory hypertension risk in hemodialysis patients. There was also a positive correlation between IL 17and Ang II.

Keywords: Interleukin 17, Angiotensin II, refractory hypertension, hemodialysis